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KMID : 0858420100120010013
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Korean Journal of Stroke
2010 Volume.12 No. 1 p.13 ~ p.16
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Stroke Update 2009: Basic/Translational Stroke Research
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Kim Dong-Eog
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Abstract
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Translational research helps translate scientific discoveries from bench to clinic. In this brief review, the results of recent translational stroke research are summarized. It covers following topics: 1) peroxisome proliferator-activated receptor-γ (PPAR-γ) to protect against ischemic cerebral infarction, 2) N-methyl-d-aspartate glutamate (NMDA) receptor-dependent activation of sterol regulatory element binding protein-1 (SREBP-1) in ischemic neuronal injuries, 3) regulatory T cells as cerebroprotective immunomodulators in stroke, 4) cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury, 5) reduction of endoplasmic reticulum (ER) stress and alleviation of atherosclerosis, 6) platelet dense-granule secretion to play a critical roles in thrombosis and subsequent vascular remodeling, and 7) pericyte contraction induced by oxidative-nitrative stress and noreflow phenomenon in cerebral infarction.
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KEYWORD
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Translational research, Basic research
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